Wild Ideas 1: Should we be finding effective treatments for the parasite Toxoplasma gondii
Could Toxoplasma gondii be the cause of "syndromes" like fibromyalgia and long covid, some brain function problems, and maybe even some cancers?
I am unvaxxed
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How I research
When I am researching something, I let the results of my questioning lead to new questions, that lead to further new questions. Sometimes I just end up getting lost down tangents and learning nothing much at all, or learning too much that I cannot put together, but sometimes these tangents take me round in circles back to the same point. When they do that, over and over again, I pay attention and try to connect all the disparate tangents into one neat picture.
One point I have kept returning to is the idea that everything that is wrong with me is parasitic in origin including covid, long covid and cancer.
With my disastrous health decline in the last two years, since I was hospitalized in 2022 with “supposed covid”, I have been trying to uncover if there is potentially a common cause, some kind of parasite, behind each of the health issues I have suffered in the last two years. I have written about my health decline in detail in other posts.
Looking for a parasite that might be the cause of FMS
I specifically started to explore further, whether my lifetime battle with Fibromyalgia (FMS), that I had nicely controlled until 2022, may have been caused by parasites. I started to speculate that maybe everything currently afflicting me is parasitic in nature.
Surely, as I have been taking powerful anti-parasitic protocols since the start of 2024, when diagnosed with cancer, there should have been some noticeable improvement in the FMS, but there has not, and the FMS has now become almost completely disabling.
I have been learning how evasive parasites can be, hiding themselves from the immune system and rendering themselves impregnable by the poisons sent to disrupt them. So I started to ask the question:
Is there some obscure and hidden parasite involved in FMS?
My research did not lead me to a clear candidate, only to the realisation that research on FMS has made absolutely zero progress in the last 20-30 years since I last did a deep dive to try to find a cure. However, one parasite grabbed my attention.
One candidate is Toxoplasma gondii
One parasite that kept turning up on tangents I was researching, was Toxoplasma gondii, which is endemic to my childhood home in England:
This parasite is very common in western countries, particularly cat-loving countries and also countries with high feral cat populations.
It can almost completely evade even a healthy human immune system and remain active but controlled in the body for life.
It can hide almost perpetually in it’s cyst form, and reactivate to a dangerous level when the immune system is compromised.
Toxoplasma gondii is a protozoan, meaning it is a single-celled organism. It is an obligate intracellular parasite, which means it must live and reproduce within the cells of its host. It can establish a lifelong infection in humans.
The Toxoplasma gondii lifecycle
Here’s what we need to know about the lifecycle of the Toxoplasma gondii.
Step 1, from Oocysts via Bradyzoites to Tachyzoites
Humans can become infected by ingesting tissue cysts in under-cooked meat or through ingestion of oocysts from contaminated food, water, or soil.
Once inside the human body, the cysts release bradyzoites, which can transform into rapidly multiplying tachyzoites.
Tachyzoites can invade various tissues and organs of the human host.
Tachyzoites can undergo asexual reproduction within human cells, leading to the spread of infection throughout the body.
In healthy individuals with intact immune systems, the infection may remain asymptomatic or cause mild symptoms resembling flu.
In immune compromised individuals, the tachyzoites cause disease. For details see Step 3.5 below.
Step 2, back from tachyzoites to bradyzoites within tissue cysts
Some tachyzoites can convert back into bradyzoites within tissue cysts, particularly in neural and muscular tissues. This is the chronic, latent phase of infection in humans.
These tissue cysts containing bradyzoites, are the slow-growing, dormant form of the parasite.
Once tissue cysts are formed, the Toxoplasma gondii can evade the immune system, so that the body does not completely eliminate it.
It can can alter host immune signaling pathways to avoid detection and destruction.
It can reside inside host cells, particularly immune cells and neurons, thus evading immune surveillance.
The cyst wall is able to protect the bradyzoites from host immune defenses.
These cysts are generally asymptomatic and do not cause significant problems in healthy individuals with intact immune systems.
Step 3, reactivation from Bradyzoites to Tachyzoites
While Toxoplasma gondii can remain latent even in immuno-competent individuals, it can reactivate and cause disease when that immune system is weakened for some other reason.
The weakened immune response may no longer effectively control the dormant cysts of Toxoplasma gondii.
The bradyzoites within tissue cysts can proliferate and convert back into active tachyzoites.
Upon reactivation, the tachyzoites can rapidly invade and multiply within various host cells, particularly in tissues where tissue cysts are present.
The invasion of tachyzoites into host cells can lead to tissue damage and inflammation at the sites of infection. This can result in local tissue destruction and disruption of normal cellular functions. Reactivated tachyzoites can invade and damage multiple body systems:
Central Nervous System (CNS)
Eyes (Ocular System)
Lymphatic System
Musculoskeletal System
Respiratory System
Gastrointestinal System
Cardiovascular System
For anyone who wants to understand more about the lifecycle of Toxoplasma gondii, the following is a good article and the source of the great little video that you can watch by clicking the heading image above.
The life-cycle of Toxoplasma gondii reviewed using animations
Conclusions
For anyone paying attention, you will see that the proliferation of this parasite could result in the set of symptoms that are called fibromyalgia, or the set of symptoms that are called long covid, or the set of symptoms of any number of other slow and grinding diseases, particularly those known as the syndromes. It is also possible that, through its ability to influence cancer-related pathways, it may be linked to cancer development.
Anti-parasitic treatments for protozoan infections including toxoplasmosis
Since my diagnosis with cancer earlier this year, I have been taking powerful anti-parasitic protocols to treat the cancers. I had been hoping that they might also knock back the symptoms of long covid and the symptoms of fibromyalgia. However, any improvements in that arena have been minimal, leaving me wondering if I am wrong about parasites being behind FMS, or alternatively, if the anti-parasitics for cancer are not effective against protozoan parasites like Toxoplasma gondii.
Upon investigation I find that the anti-parasitics I have been taking, whilst having significant anti-parasitic and anti-cancer effects, DO NOT have any significant impact on protozoan parasites of which Toxoplasma gondii is one.
There are foods that can knock back the active form of toxoplasmosis and so are able to reduce the level of infestation, but there are few natural products that are able to disrupts the cysts that are waiting dormant, to become active during the next down-cycle of your immune system.
Piper nigrum, Capsicum frutescens, Cinnamomum cassia and Curcuma longa
In this study, water and ethanol extracts as well as the oil of some home spices (Piper nigrum, Capsicum frutescens, Cinnamomum cassia and Curcuma longa), were evaluated. Female mice were infected with tachyzoites and then treated intraperitoneally with the home spices at 100 and 200 mg/kg/day for seven days.
I worked out that the equivalent dose for humans would be about 9 grams a day for a 90kg person, over 7 days. That’s pretty high so I would want to do a lot more research before I took that dose. I would also want to know if it is a safe at that level, and if it just removes the tachyzoites or is also able to destroy the cysts.
My next steps
My next step is to get a medical test to see if I have toxoplasmosis, either active or latent, and if the answer is yes, then I will have to find:
the best way to destroy the active tachyzoites, which should reduce or remove symptoms short term, and
the best way to destroy the cysts and their payload of bradyzoites so the active tachyzoites do not come back.
I gather this is not going to be easy.
Can you help?
I intend to keep writing of my journey through this rather strange time in my life, and for this planet. As soon as I know, you will know what does and does not work to exorcise this bio-weapon from our bodies.
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I think you will find that all these ailments are caused by frequency modulation equipment & noy by parasitic infestations.
No worries, increase the amount gradually, the body adapts, if done too quickly your body will speak loud enough via symptoms: the big 'D',nausea, etc!
Agree not even our roses smell as sweet...
Our 'improved' farmers market:
3 veggie stands, I ( Amazon feed fed egg vendor) the rest,
'Artisan' breads, cookies, sandwiches etc. 🤓